Genetic
& Molecular Epidemiology
In Genetic and Molecular Epidemiology the group
has three main themes
of research: integrative polygene analyses, mRNA functional studies and
rarer sequence variants at the population level. A small sample of
publications:
- Day
IN, Rodriguez S, Kralovicova J, Wood PJ,
Vorechovsky I, Gaunt TR. Questioning INS VNTR role in
obesity and
diabetes:subclasses tag IGF2-INS-TH haplotypes;and
-23HphI as
a
"STEP" (splicing and translation efficiency polymorphism). Physiol
Genomics. 2006 [Epub ahead of print]
- Alharbi KK, Spanakis E, Tan K,
Smith MJ, Aldahmesh MA,
O'dell SD, Sayer AA, Lawlor DA, Ebrahim S, Smith GD, O'rahilly S,
Farooqi S,
Cooper C, Phillips DI, Day IN. Prevalence and functionality of
paucimorphic and
private MC4R
mutations in a large, unselected European British
population,
scanned by meltMADGE Hum
Mutat. 2006 [Epub ahead of print]
- Rodriguez S, Gaunt TR, O'Dell SD, Chen XH, Gu D, Hawe
E,
Miller
GJ, Humphries SE, Day IN. Haplotypic analyses of the IGF2-INS-TH gene
cluster in relation to cardiovascular risk traits. Hum
Mol Genet. 2004 13(7):715-25.
