Genetic
& Molecular Epidemiology
In Genetic and Molecular Epidemiology the group
has three main themes
of research: integrative polygene analyses, mRNA functional studies and
rarer sequence variants at the population level. A small sample of
publications:
- Shah S*, Nelson CP*, Gaunt TR*, van der Harst P, Barnes T, Braund PS, Lawlor DA, Casas JP, Padmanabhan S, Drenos F, Kivimaki M, Talmud PJ, Humphries SE, Whittaker J, Morris RW, Whincup PH, Dominiczak A, Munroe PB, Johnson T, Goodall
AH, Cambien F, Diemert P, Hengstenberg C, Ouwehand WH, Felix JF, Glazer NL, Tomaszewski M, Burton PR, Tobin MD, van Veldhuisen DJ, de Boer RA, Navis G, van
Gilst WH, Mayosi BM, Thompson JR, Kumari M, Macfarlane PW, Day IN*, Hingorani AD*, Samani NJ*. [* equal authorship] Four Genetic Loci Influencing Electrocardiographic Indices of Left Ventricular
Hypertrophy. Circ Cardiovasc Genet. 2011 Sep 30; [Epub ahead of print]
- Raistrick CA, Alharbi KK, Day IN, Gaunt TR. Analysis of Potential Genomic Confounding in Genetic Association Studies and an
Online Genomic Confounding Browser (GCB). Ann Hum Genet. 2011 Nov;75(6):723-31.
- Davies NM, Windmeijer F, Martin RM, Abdollahi MR, Smith GD, Lawlor DA, Ebrahim S, Day IN. Use of genotype frequencies in medicated groups to investigate prescribing
practice: APOE and statins as a proof of principle. Clin Chem. 2011 Mar;57(3):502-10. Epub 2011 Jan 12.
- Taylor AE, Guthrie PA, Smith GD, Golding J, Sattar N, Hingorani AD, Deanfield JE, Day IN. IQ, educational attainment, memory and plasma lipids: associations with
apolipoprotein E genotype in 5995 children. Biol Psychiatry. 2011 Jul 15;70(2):152-8. Epub 2011 Jan 7.
- International Consortium for Blood Pressure Genome-Wide Association Studies Genetic variants in novel pathways influence blood pressure and cardiovascular
disease risk. Nature. 2011 Sep 11;478(7367):103-9.
- Alfred T, Ben-Shlomo Y, Cooper R, Hardy R, Cooper C, Deary IJ, Elliott J, Gunnell D, Harris SE, Kivimaki M, Kumari M, Martin RM, Power C, Sayer AA, Starr
JM, Kuh D, Day IN; HALCyon Study Team. Absence of association of a single-nucleotide polymorphism in the TERT-CLPTM1L
locus with age-related phenotypes in a large multicohort study: the HALCyon
programme. Aging Cell. 2011 Jun;10(3):520-32. Epub 2011 Apr 7.
- Alfred T, Ben-Shlomo Y, Cooper R, Hardy R, Cooper C, Deary IJ, Gunnell D, Harris
SE, Kumari M, Martin RM, Moran CN, Pitsiladis YP, Ring SM, Sayer AA, Smith GD, Starr JM, Kuh D,Day IN; and the HALCyon study team. ACTN3 genotype, athletic status, and life course physical capability:
meta-analysis of the published literature and findings from nine studies. Hum Mutat. 2011 May 3; [Epub ahead of print]
- Zabaneh D*, Gaunt TR*, Kumari M, Drenos F, Shah S, Berry D, Power C, Hypponen E, Shah T, Palmen J, Pallas J, Talmud PJ, Casas JP, Sofat R, Lowe G, Rumley A, Morris RW, Whincup PH, Rodriguez S, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Kivimaki M, Whittaker J, Hingorani AD, Day IN*, Humphries SE*. [*equal authors] Genetic Variants Associated with von Willebrand Factor Levels in Healthy Men and
Women Identified Using the HumanCVD BeadChip. Ann Hum Genet. 2011 Apr 28; [Epub ahead of print]
- Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse
SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani
AD; ASCOT investigators; NORDIL investigators; BRIGHT Consortium. Gene-centric association signals for lipids and apolipoproteins identified via
the HumanCVD BeadChip. Am J Hum Genet. 2009 Nov;85(5):628-42.
- Rodriguez S, Gaunt TR, Day IN. Hardy-Weinberg
equilibrium
testing of biological ascertainment for Mendelian randomization
studies. Am
J Epidemiol. 2009 Feb 15;169(4):505-14. Epub 2009 Jan 6.
