BGEL - Bristol Genetic Epidemiology Laboratories
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Ian Day, MB, PhD, FRCPath

Professor of Molecular and Genetic Epidemiology

Bristol Genetic Epidemiology Laboratories,
Dept. Social Medicine,
University of Bristol,
Canynge Hall,
Whiteladies Road,
Bristol BS8 2PR

 ian.day@bristol.ac.uk
I qualified from the University of Oxford in 1980 with First Class Honours in Physiological Sciences and gained my medical degree with distinction from the University of Cambridge in 1982.  My PhD, undertaken on an MRC Training Fellowship in the Department of Clinical Biochemistry in Cambridge, was in the protein chemistry, immunochemistry and molecular cloning of the protein PGP9.5 and its gene (UCHL1). I accredited in medical biochemistry and completed the MRCPath (in Chemical Pathology) in 1992. From 1992-1995 I held a BHF Intermediate Fellowship at UCLMS and from 1996-2000 was a Lister Institute Fellow. From 1997-2006 I was Professor of Human Genetics at the University of Southampton. Since 1993 much of my research has been in the genetics of cardiovascular diseases and risk factors. To 2006, I have published over 120 original papers, 50 reviews and chapters, and edited 4 books. I have had almost continuous UK research funding from MRC since 1984 and BHF since 1992 and numerous other funding support ranging from building, JREI, SRIF and other infrastructure awards, to a range of focused project grants. I was head of the Division of Human Genetics (~150 staff and students) in Southampton Medical School for 6 years, where I also ran a group of 15-25 researchers for 9 years. I was head of the postgraduate school of Southampton Medical School for 3 years. I have also had experience of patents, IP and a small spin-out company. I have taught medical biochemistry and genetics at BM, BSc, MSc and PhD/MD levels. I served on BHF project grants panel for 4 years, am a member of MRC College of Experts, have served on UK Foresight panel and EU funding planning panels, am a member of numerous genetics advisory committees and also the MRC DNA Banking Network Oversight Committee, I am reviews editor for Human Genetics and on the editorial board of Human Mutation. For the past decade I have been fully and continuously engaged with clinical, laboratory and statistical aspects of genetic epidemiological population and family research studies and recognise the syntheses of systems biology and hypothesis driven research and of combining technologies effectively into biomedical and translational research. 

Publications

Original Papers
  • Shuwen Huang1*, Xiao-he Chen1, John R. Payne2, Matt J Smith, Hugh E. Montgomery2, Ian Day1 and Tom Gaunt1   Haplotype of Growth Hormone and ACE Genes, Serum ACE and Ventricular Growth: Pathway Inference in Pharmacogenetics (in press, Pharmacogenetics (cat. P119)
  • Interaction between birth-weight and polymorphism in the Calcium Sensing Receptor gene in determination of adult bone mass: The Hertfordshire Cohort Study Lips MA1 , Syddall H1, Aihie Sayer A1, Gaunt TR2, Rodriguez S2, Day INM2, Cooper C1, Dennison EM1 and the Southampton Genetic Epidemiology Research Group (in press Oct 2006, J Rheumatol) (cat. P118)
  • 1Katherine Fawcett, 2Nicholas J. Wareham, 2Jian'an Luan, 3Holly Syddall, 3Cyrus Cooper, 3Ian Day  4Stephen O’Rahilly, 2,5Manjinder S Sandhu, 1Inês Barroso  The PSARL Leu262Val is not associated with fasting insulin levels in UK  populations. Diabetologia in press  (cat. P117)
  • Day IN, Rodriguez S, Kralovicova J, Wood PJ, Vorechovsky I, Gaunt TR.  Questioning INS VNTR role in obesity and diabetes:subclasses tag IGF2-INS-TH haplotypes;and -23HphI as a "STEP" (splicing and translation efficiency polymorphism). Physiol Genomics. 2006 Aug 1; [Epub ahead of print] (cat. P116)
  • Mohammad R. Abdollahi 1,3, Rohan M. Lewis 2 , Thomas R. Gaunt 1, Debbie V. E. Cumming1, Santiago Rodriguez1 , Matthew Rose-Zerilli1, Collins A R1, Holly E. Syddall 2, William M Howell1, Iain T. Cameron2, Ian N. M. Day 1. Quantitated Transcript Haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C, and relevance to metabolic syndrome traits(Hum Mutation, accepted Aug 2006) (cat.P115)
  • Khalid K. Alharbi1, Emmanuel Spanakis1, Karen Tan2, Matt J. Smith1, Mohammed A. Aldahmesh1, Sandra D. O'Dell1, Avan Aihie Sayer3, Debbie A. Lawlor4, Shah Ebrahim5, George Davey Smith4, Stephen O’Rahilly3, Sadaf Farooqi2 , Cyrus Cooper3, David I.W.Phillips3 and Ian N M Day1 Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE  (submitted Human Mutation May 2006, in revision midJune 2006 resubmitted 6-7-06 accepted 6-7-06) (cat.P114)
  • Elaine Johnstone1, Neal Benowitz2, Anna Cargill3, Patricia Yudkin4, Robyn Jacob1, Lesley Hinks5, Ian Day5, Mike Murphy6, Robert Walton1  Determinants of rate of nicotine metabolism and effects on smoking behaviour (submitted to Clin Pharm Ther 10-05, in revision Jan 2006, accepted 15-6-06) (cat.P113)
  • Gunnell D,1 Lewis S,1 Wilkinson J,2 Georgieva L,2 Davey Smith G,1 Day INM,1 Holly JMP3 O’Donovan MC,2 Owen MJ,2 Kirov G,2 Zammit S2  IGF1 and growth pathway polymorphisms and schizophrenia: a pooling Neuropsych Genet study (accepted June 2006) (cat.P112)
  • Debbie A Lawlor,1 Ian NM Day,2 Tom R Gaunt,2 Lesley J Hinks,2 Nick Timpson,1 Shah Ebrahim,3 George Davey Smith.1 The association of the PON1 Q192R polymorphism with depression in older women: findings from the British Women’s Heart and Health Study. Journal of Epidemiology and Community Health (acc.4-06 subject to minor revisions)  (cat.P111)
  • Tom R. Gaunt 1a*#, Santiago Rodriguez 1b#, Carlos Zapata 2, Ian N. M. Day 1c  MIDAS: software for analysis and visualisation of interallelic disequilibrium between multiallelic markers. BMC Bioinfomatics 7:227 (18pages+figures) (27 April 2006) (cat.P110)
  • W. Zhang*, N. Maniatis*, S. Rodriguez, G. J. Miller, I. N. M. Day, T. R. Gaunt, A. Collins, N. E. Morton  Refined association mapping for a quantitative trait: weight in the H19-IGF2-INS-TH region  Ann Hum Genet  Online publication date: 31-Mar-2006 doi: 10.1111/j.1469-1809.2006.00290.x (cat. P109)
  • Mohammad R Abdollahi 1, Philip A Guthrie 1, George Davey Smith 1, Debbie A Lawlor1, Shah Ebrahim 3, Ian N Day 2  (2006) Integrated Single Label Liquid Assay of APOE Codons 112 and 158 and Lipoprotein Study in British Women. In press Clinical Chemistry  Jul;52(7):1420-3. Epub 2006 Apr 27. (cat. P108)
  • Debbie A Lawlor,1 Nick Timpson,1 Shah Ebrahim,1 Ian NM Day,1,2 George Davey Smith  The association of estrogen receptor α haplotypes ((ESR1): c454-397T>C (rs2234693) and c454-351A>G (rs9340799)) with hormone replacement and cardiovascular risk factors in the British Women’s Heart and Health Study. In press Eur Heart J Feb 2006 (cat. P107)
  • Shuwen Huang, Xiao-he Chen, Ian N M Day Combination of 768 well microplate array diagonal gel electrophoresis with duplex PCR of X and Y chromosome markers for quality control of epidemiological DNA banks.   (submitted to Electrophoresis 30-09-05, accepted without revisions 4/2/06, in press) (cat. P106)
  • M. B. Christensen,1 D. A. Lawlor, †2 T. R. Gaunt,1  M. W. Howell,1 G. Davey Smith,2 S. Ebrahim,2 I. N. M. Day†1,2   Genotype of galectin 2 (LGALS2) is associated with insulin-glucose profile in the British Women’s Heart and Health Study.Diabetologia (in press,  29-11-05) 2006 Apr;49(4):673-7. Feb 9;:1-5 [Epub ahead of print] (cat. P105)
  • Sarah J Lewis1, Debbie A Lawlor1, George Davey Smith1, Ricardo Araya2, Nick Timpson1, Ian NM Day1, Shah Ebrahim1. The thermolabile variant of MTHFR is associated with depression in the British Women’s Heart and Health Study and a meta-analysis., in press 11-05 for Molecular Psychiatry  (cat P104)
  • Nicholas J Timpson, Debbie A Lawlor, Roger M Harbord, Tom R Gaunt, Ian N Day, Lyle J Palmer, Andrew T Hattersley, Shah Ebrahim, Gordon D O Lowe, Ann Rumley, George Davey Smith. (2005) C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. In press, Lancet, proofs 19-10-05 Lancet. 2005 Dec 3;366(9501):1954-9.  (cat. P103)
  • J Kralovicova, S Rodriguez, TR Gaunt, PJ Wood, INM Day, I Vorechovsky (2006). Variants in the human insulin gene that affect pre-mRNA splicing: is -23HphI a functional SNP at IDDM2? Diabetes 55 (1): 260-264, January 2006 [Patent application GB 0510555.6 filed 25-5-05]  (cat.P102)
  • Santiago Rodríguez, Tom R Gaunt, Xiao-he Chen, Holly E Syddall, Cyrus Cooper, David I W Phillips & Ian N M Day. 2005. Replication of IGF2-INS-TH *5 haplotype effect on obesity and study of related phenotypes in older men Eur J Hum Genet, 14(1):109-16 (cat. P101)
  • Santiago Rodríguez1, Shuwen Huang1, Xiao-he Chen1, Tom R. Gaunt1, Holly E. Syddall2, Julie Gilg3, George G. Miller, Cyrus C. Cooper2, Derek G. Cook3, Peter H. Whincup3 and Ian N.M. Day1 (2006) A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys Pharmacogenetics & Genomics. 16(1):15-23, January 2006  (cat. P100)
  • Debbie A Lawlor,1 Tom R Gaunt,2 Lesley J Hinks,2 George Davey Smith,1 Nick Timpson,1 Ian NM Day,2 Shah Ebrahim.1 The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women’s Heart and Health cohort study.  Paediatric and Perinatal Epidemiology (accepted subject to minor revisions 24-07-05) (cat. P99)
  • 1Shuwen Huang, 2Derek G. Cook, 1Lesley 1J Hinks, 1Xiao-he Chen, 1Shu Ye, 2Julie A. Gilg, 3Martin J. Jarvis, 2Peter H. Whincup and *1Ian N.M. Day (2005) CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1,518 UK adolescents  Pharmacogenetics and Genomics, 15 (12), 839-850 December 2005 (cat. P98)
  • Haixin Lei, Ian N M Day, Igor Vorechovsky. 2005 Exonization of  AluYa5 in the human ACE gene requires mutations in both 3’ and 5’ splice sites and is facilitated by a conserved splicing enhancer. Nucleic Acids Research, 33(12):3897-906 http://nar.oxfordjournals.org/cgi/content/full/33/12/3897 http://www.pubmedcentral.gov/articlerender.fcgi?tool=pubmed&pubmedid=16027113 (cat. P97)
  • Khalid K. Alharbi1, Mohammed A. Aldahmesh1,  Emmanuel Spanakis1†, Lema Haddad2‡, Rosalind A. Whittall2, Xiao-he Chen1, Hamid Rassoulian3, Matt J. Smith1, Julie Sillibourne, Nicola J. Ball1, Nikki J. Graham1, Patricia J. Briggs1. Iain A. Simpson4, David I. W. Phillips5, Deborah A. Lawlor6, Shu Ye1, Stephen E. Humphries2, Cyrus Cooper5, George Davey Smith6, Shah Ebrahim6, Diana M Eccles, Ian N. M. Day1*  (2005) Mutation scanning by meltMADGE: validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare and paucimorphic mutations in the general population. Genome Research, 15(7): 967-977 (cat.P96)
  • Matt J. Smith1, Gabriella Pante-de-Sousa1,2, Khalid K. Alharbi1, Xiao-he Chen1, Ian N. M. Day*1, Keith R. Fox3  Combination of His-tagged T4 endonuclease VII with MADGE for high throughput mutation scanning.  Clinical Chemistry 2005; 51:1043-1046 and supplementary data at http://www.clinchem.org/cgi/content/abstract/51/6/1043  (cat. P95)
  • George Davey Smith, Debbie A Lawlor, Roger Harbord, Nic Timpson, Ann Rumley, Gordon D O Lowe, Ian NM Day, Shah Ebrahim Association of C-reactive protein with blood pressure and hypertension: lifecourse confounding and Mendelian randomisation tests of causality. Arterioscler Thromb Vasc Biol. 2005 May;25(5):1051-6. Epub 2005 Feb 24 (cat. P94)
  • Nic Timpson1, Debbie A Lawlor1, Mikkel Christensen2, Tom R Gaunt2,, Ian N Day1,2,  Shah Ebrahim1, George Davey Smith1   TAS2R38 (PTC) haplotypes, coronary heart disease traits and eating behaviour in the British Women’s Heart and Health Study Am J Clin Nutr. 2005 May;81(5):1005-11 (cat. P93)
  • 1MR Abdollahi , 1TR Gaunt, 2HE Syddall,  2C Cooper, 2DIW Phillips, 1S Ye, 1Ian NM Day. Angiotensin II Type I Receptor Gene Polymorphism, Anthropometric and Metabolic Syndrome Traits. J Med Genet. 2005 May;42(5):396-401.  (cat. P92)
  • Santiago Rodríguez1, Xiao-he Chen1, George J. Miller2 and Ian N. M. Day1 (2005)  Nonrecombining chromosome Y haplogroups and centromeric HindIII RFLP in relation to blood pressure in 2743 middle-aged Caucasian men from the UK Human Genetics 116: 311-318 (cat.P91)
  • Clive Holmes, Clive Ballard, Donald Lehmann, A David Smith, Helen Beaumont, Ian N Day, M Nadeem M Khan, Simon Lovestone, Michelle McCulley, Christopher M Morris, David G Munoz, Kirsty O’Brien, Carsten Russ, Teodoro Del Ser and Donald Warden. Rate of Progression of Cognitive decline in Alzheimer's Disease: effect of Butyrylcholinesterase K Gene Variation.  J Neurol Neurosurg Psychiatry 2005 May;76(5):640-3. (cat. P90)
  • *1Ian N M Day, 1†Xiao-he Chen, 1†Tom R Gaunt, 1Tabitha H T King, 1Anca Voropanov, 1Shu Ye, 1†Santiago Rodriguez, 2Holly E Syddall, 2Avan Aihie Sayer, 2Elaine M Dennison, 2Faiza Tabassum, 2David J P Barker, 2Cyrus Cooper, 2David I W Phillips.(2004)  Late life metabolic syndrome, early growth and common polymorphism in the growth hormone and placental lactogen gene cluster J Clin End Metab 89 (11) 5569-5576 (cat. P89)
  • Debbie A Lawlor,1 Ian NM Day,2 Tom R Gaunt,2 Lesley J Hinks,2 Patricia J Briggs,2 Matthew Kiessling,2 Nick Timpson,1 George Davey Smith,1 Shah Ebrahim.1 (2004) The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women’s Heart and Health prospective cohort study and a meta-analysis. BMC Genetics 5: 17 (12 pages) (cat.P88)
  • Testing for population subdivision and association in a UK-wide epidemiological survey  †Xiao-he Chen1, †Santiago Rodríguez1, Emma Hawe2, Peter Underhill, George J Miller3, Stephen E Humphries2, Ian NM Day1 (2004) Human Heredity 57(3) 142-55 (cat.P87, pdf)
  • Dennison EM1,  Voropanov A2, Syddall H1, Day I2 , Cooper C1 and the Southampton Genetic Epidemiology Research Group+ (2004). Polymorphisms Of The Growth Hormone Gene, Weight in Infancy, and Adult Bone Mass. J Clin End Metab 89 (10) 4898-903   (cat.P86)
  • Santiago Rodríguez1†*, Tom R. Gaunt1†, Sandra D. O’Dell1§, Xiao-he Chen1, Dongfeng Gu1‡, Emma Hawe2, George J Miller3, Stephen E. Humphries2 and Ian N. M. Day1  (2004) Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits Human Molecular Genetics Apr 1;13(7):715-25. Epub 2004 Jan 28 (cat.P85, pdf)
  • Santiago Rodríguez, Xiao-he Chen and Ian N. M. Day. (2004) Typing dinucleotide repeat loci using Microplate Array Diagonal Gel Electrophoresis: proof of principle. Electrophoresis,  Apr;25(7-8):975-9. (cat.P84, pdf)
  • Marchbanks RM, Ryan M, Day IN, Owen M, McGuffin P, Whatley SA (2003) A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress. Schizophr Res. Dec 1;65(1):33-8.  (cat.P83)
  • Ye S, Dhillon S, Seear R, Dunleavey L, Day LB, Bannister W, Day IN, Simpson I. Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis. Heart. 2003 Oct;89(10):1195-9 (cat.P82)
  • McCulley, MC, Day, INM, Holmes, C. (2003)  Association between interleukin 1-β promoter (-511) polymorphism and depressive symptoms in Alzheimer’s disease. Am J Med Genet Part B (Neuropsych Genet) (in press) (cat.P81)
  • Beyzade, S., Zhang, S., Wong, Y., Nagase, H., Day, I.N.M., Eriksson, P., Ye, S. (2003) Influences of matrix metalloproteinase-3 gene variation on extent of coronary atherosclerosis and risk of myocardial infarction. Journal of American College of Cardiology 41: 2130-2137. (cat.P80)
  • Shu Ye, Louise Dunleavey, Wendy Bannister, Lorna B Day, William Tapper, Andrew R Collins, Ian NM Day, Iain Simpson (2003)  Independent effects of the -219 G>T and E2/E3/E4 polymorphisms in the apolipoprotein E gene on coronary artery disease. The Southampton Atherosclerosis Study (SAS). European Journal of Human Genetics 11, 437-443 (cat. P79, pdf, full text)
  • †1Tom R Gaunt, †1Lesley J Hinks,  2Hamid Rassoulian and *1Ian N M Day (2003). Manual 768 or 384-well microplate gel dry electrophoresis for PCR checking and SNP genotyping  Nucleic Acids Res 31(9) e48 (10 pages)   (cat. P77, pdf) http://nar.oupjournals.org/cgi/content/full/31/9/e48?ijkey=17KW9RLpnLcn2&keytype=ref
  • A Aihie Sayer1,3 ,H Syddall1, SD O’Dell2, X Chen2, PJ Briggs2, R Briggs3, INM Day2, C Cooper1 (2002) Polymorphism of the IGF2 gene, birth weight and grip strength in adult men Age and Ageing 31, 468-470 (cat. P76)
  • Ian N M Day, Tabitha H T King, Xiao-he Chen, Anca M Voropanov, Shu Ye, Holly E Syddall, Avan Aihie Sayer, Cyrus Cooper, David J Barker, David I W Phillips. Insulin-like growth factor I genotype and birthweight.  Lancet, 360, 945-946 (cat. P74)
  • O’Dell SD, Syddall HE, Sayer AA, Cooper C, Fall, CHD, Dennison EM, Phillips DIW, Gaunt TR, Briggs PJ, Day, INM (2002).  Null mutation in human ciliary neurotrophic factor gene confers higher body mass index in males  Eur J Hum Genet 10, 749-752 (cat. P75, pdf, full text)
  • Chen X, O’Dell SD, Day, INM. (2002) Microplate diagonal gel electrophoresis for cohort studies of microsatellite loci.  BioTechniques, 32, 1080-1089  (cat. P73, pdf)
  • Gu D, O’Dell SD, Chen X, Miller GJ, Day, INM (2002).  Localisation of causal sites affecting weight in the IGF2-INS-TH region of human chromosome 11. Human Genetics 110 (2), 173-181  (cat. P72, pdf)
  • Zhang J, Day INM, Byrne CD (2002).  A novel medium throughput quantitative competitive PCR technology to simultaneously measure mRNA levels from multiple genes. Nucleic Acids Research 30(5): e20, 1-10  (cat. P71)
  • Zhang B, Dhillon S, Geary I, Howell WM, Iannotti F, Day INM, Ye S (2001).  Polymorphism in matrix metalloproteinase-1, 3, 9 and 12 genes in relation to subarachnoid hemorrhage.   Stroke 32: 2198-202  (cat. P68)
  • Day, I.N.M. and Wilson, D.I (2001).  Science, medicine, and the future: Genetics and cardiovascular risk. British Medical Journal 323(7326):1409-1412. (Cat. CR36)
  • Humphries, S.E., Talmud, P.J., Hawe, E., Bolla, M., Day, I.N.M., Miller, G.J. APOE4 increases the risk of coronary heart disease in middle-aged men who smoke: second Northwick Park Heart Study.  Lancet, 358, 115-119, July 2001 (cat. P67, pdf)
  • Ye S, Dhillon S, Ke X, Collins A.R., Day, INM (2001) An efficient procedure for genotyping single nucleotide polymorphisms. Nucleic Acids Res 29: 88 (8 pages) (cat. P70, pdf, html)
  • Emmanuel Spanakis, Mohammed Al-Dahmesh and Ian N.M. Day Scanning for point variation in large populations by melt-MADGE. Trends in Genetics/ Technical Tips Online, 2001, 1:117:P02204 (cat. P66)
  • Gaunt TR, Cooper JA, Miller GJ, Day INM, O’Dell SD.  Positive associations between SNPs in the IGF2 gene region and body mass index in adult males. Hum Mol Genet 10 (14), July 2001, 1491-1501  (cat. P65)
  • Zhang S, Day, INM, Ye S.  Microarray analysis of nicotine induced changes in gene expression in endothelial cells. Physiol. Genomics 2001;5 187-192 (full paper and suppl info online http://physiolgenomics.physiology.org/cgi/content/abstract/5/4/187  (Cat. P64, pdf, html)
  • Xiao-He Chen, Sandra D. O'Dell, Lesley J. Hinks, Emmanuel Spanakis, Tom R. Gaunt, Rosalind H. Ganderton and Ian N.M. Day High-resolution MADGE. Trends in Genetics/ Technical Tips Online, 2001, 1:116:T02156  (Cat. P63)
  • Ye S, Dhillon S, Turner SJ, Bateman AC, Theaker JM, Pickering RM, Day I, Howell WM.  Invasiveness of cutaneous malignant melanoma is influenced by matrix metalloproteinase I gene polymorphism. Cancer Res. 61, 2000, 1296-1298. (Cat. P62, pdf)
  • Tom R. Gaunt, Lesley J. Hinks, Xiao-he Chen, Sandra D. O'Dell, Emmanuel Spanakis, Rosalind H. Ganderton and Ian N.M. Day  (2000) 384-well MADGE for high-throughput DNA-bank studies.) Trends in Genetics/ Technical Tips Online  1: Core Protocols P02069.(Cat. P61)
  • Rosalind H. Ganderton, Sandra D. O'Dell, Tom R. Gaunt, Xiao-he Chen, Lesley J. Hinks, Emmanuel Spanakis and Ian N.M. Day (2000) Microplate-array diagonal-gel electrophoresis (MADGE) systems for high-throughput electrophoresis Trends in Genetics/ Technical Tips Online  1: Core Protocols P02068 (Cat. P60)
  • Dennison, E.M., Arden, N.K., Keen, R.W., Syddall, H., Day, I.N.M., Spector, T.D., Cooper, C (2001). Birthweight, vitamin D receptor genotype and the programming of osteoporosis.  Paediatric Perinatal Epidemiology 15: 211-219 (cat. P69)
  • Zhang, S.L., Day, I..N.M., Ye, S. Nicotine induced changes in gene expression by human coronary artery endothelial cells. Atherosclerosis 154, Jan. 2001, 277-283. (Cat. P59, pdf, full text)
Chapters and Reviews
  • Day, I.N.M., Spanakis, E., Hinks, L.J., Voropanov A., Chen, X., O’Dell, S.D. (2001) Microplate array diagonal gel electrophoresis (MADGE) methodologies: the first five years. Chapter 7 in Day, I.N.M. (editor) Book ‘Molecular Genetic Epidemiology – A Laboratory Perspective’ Cambridge, Springer-Verlag, Berlin, Heidelberg, New York 2001, pp 157-181.  (Cat. CR35)

  • *IN.M. Day, M.A.Al-Dahmesh#, K.K. Alharbi#,  X.Chen#, R.H.Ganderton#, T.R. Gaunt#, L.J. Hinks#, S.D. O’Dell1#, E. Spanakis2#, P.J.R. Day3, M.A. Suchard4 , B.B. Zhang5, M.R. James6 Electrophoresis in microplate formats. Chapter in Ye, S and Day, I.N.M (eds) Book ‘Microarrays and microplates’ BIOS Press, Oxford, UK, 2003 (Cat. CR44, pdf)

  • MeltMADGE: economical very high throughput mutation scanning using thermal ramp electrophoresis in conjunction with MADGE (microplate array) gels *I.N.M. Day, M.A.Al-Dahmesh, L. Haddad1, K.K. Al-Harbi, X.Chen, H. Rassoulian2, S.E. Humphries3, E. Spanakis4, D. Eccles (Chapter 9 (and protocols chapter 35) in Mutation Detection, Wiley, eds GR Taylor, INM Day) 2005 (Cat.CR41)

  • *Ian N M Day,  Rosalind H Ganderton, †Xiao-he Chen, †Tom R Gaunt  Microplate Array Diagonal Gel Electrophoresis For SNP And Microsatellite Genotyping And For Mutation Scanning. in  Encyclopedia of Diagnostic Genomics and Proteomics (EDGP) edited by Jürgen Fuchs and Maurizio Podda pp.836-841 2005 Marcel Dekker, Inc (Cat.CR42)
  • Experience applying LightTyper methodology to human SNPs relevant to growth and cardiovascular risk. *Tom R Gaunt, Lesley J Hinks, Mikkel B Christensen, Matthew Kiessling, Ian N. M. Day Chapter 5 in Genetic Variance Detection: technologies for pharmacogenomics (ed Karl Hecker) DNA Press pp 131-144 (Cat. CR45)
  • MADGE-based technologies for identification of unknown mutations at the population level. Matt  Smith1, Khalid K. Alharbi1, Mohammed A Aldahmesh, Gabriella Pante-de-Sousa1,2, Guangwei Hou, Xiao-he Chen1, Diana M. Eccles, Keith R.Fox3, Ian N. M. Day1 Chapter 6 in Genetic Variance Detection: technologies for pharmacogenomics (ed Karl Hecker) DNA Press pp 145-162(Cat. CR46)
  • Genetic endocrinology of the metabolic syndrome:networks of genotype-determined feedback loop setpoints Santiago Rodríguez 1, Tom R Gaunt 1, Mohammad Reza Abdollahi 2, Sabine Sonnenberg 1 and Ian N M Day Nova Book, accepted -7-06 (Cat.CR49)
  • Day, I.N.M.  Use of genetic profiling in cardiovascular disease. Key Opinion (Editorial) for InCirculation.net. 2003 (CR43, html)
  • Day, Ian; Rodriguez, Santiago; Kralovicova, Jana; Wood, Peter; Vorechovsky, Igor; Gaunt, Tom. Questioning INS VNTR role in obesity and diabetes:subclasses tag IGF2-TH-INS haplotypes;and -23HphI as a STEP(splicing and translation efficiency polymorphism) Physiological Genomics (accepted 4-7-06) (CR50)
  • Dr. Santiago Rodríguez, Dr. Tom R Gaunt, Shuwen Huang, Dr. Mohammad R. Abdollahi, Dr. Khalid Al-Harbi, Dr. Xiao-he Chen and Professor Ian N. M. Day. Genomic applications of Microplate-Array Diagonal-Gel Electrophoresis (MADGE): Approaches for SNPs, microsatellites, RNA expression and unknown mutations.  BIOforum Europe 01/2005, pp 42–43, GIT VERLAG GmbH & Co. KG, Darmstadt, Germany, www.gitverlag.com/go/bioint (Cat. CR47) . Selected for republication in BIOforum Europe Highlights issue for 2006, 01/2006, pp 52-53.
  • *Tom R Gaunt, Lesley J Hinks, Mikkel B Christensen, Matthew Kiessling, Ian N. M. Day. Uses of the LightTyper in human genotype analysis: SNPs, microhaplotypes and large insertion/deletions. Biochemica 2005, issue 2 pages 04-06 http://www.roche-applied-science.com/PROD_INF/BIOCHEMI/no2_05/pdf/p04.pdf (CR48) reprinted in New Drugs, http://www.new-drugs.com/index.html, xx/05
  • *Tom R Gaunt, Lesley J Hinks, Mikkel B Christensen, Matthew Kiessling, Ian N. M. Day. Uses of the LightTyper in human genotype analysis: SNPs, microhaplotypes and large insertion/deletions.. Reprint of CR48 in New Drugs.  http://www.new-drugs.com/index.html
  • Day, I.N.M., Gu D, Ganderton RH, Spanakis, E., Ye, S (2001).  Epidemiology and the genetic basis of disease.  Int. J. Epidemiol. 30: 661-667
  • Day INM (2003) Monogenic Hypercholesterolemia: Genetics. In: Cooper DN (ed.) Nature Encyclopedia of the Human Genome, vol. 4, article A5940 pp. 69-74. London: Nature Publishing Group. (Cat. CR39). Now integrated (2006) following buy of EHG by John Wiley & Sons Ltd, Chichester UK, into Encyclopedia of Life Sciences (ELS) Online.
  • 1Baiping Zhang, 2Kaare Fugleholm, 1Lorna B Day, 1Shu Ye, 2Roy O Weller, 1Ian N M Day* (2003) Molecular pathogenesis  of  subarachnoid haemorrhage.  Int J Biochem Cell Biol (submitted by ID 10/02, minor revisions requested and completed 6/12/02, accepted, proofs 02/03, in press) 35, 1341-1360 (Cat. CR37, pdf)
  • Day, I.N.M.  (2004) In what situations is genetic testing currently useful for management of individual patients to prevent or treat cardiovascular disease?  Dialogues in Cardiovascular Medicine 9(1) 23-29  (Cat. CR38)
  • Ian N M Day, † Khalid K Alharbi, † Matt Smith, Mohammed A. Aldahmesh, Xiao-he Chen, Andrew J. Lotery, 1Gabriella Pante-de-Sousa, Guangwei Hou, Shu Ye, Diana Eccles, Nicholas C P Cross, 2Keith R Fox, Santiago Rodriguez (2004) Paucimorphic alleles versus polymorphic alleles and rare mutations in disease causation: theory, observation and detection Current Genomics, 5, 431-438  (Cat. CR40)
Books edited
  • Taylor, G.R. and, Day, I.N.M. (eds) Mutation Detection Wiley Press (2005)
  • Ye, S and Day, I.N.M. (eds) Book ‘Microarrays and microplates: applications in the biosciences’ BIOS Press, Oxford, UK 2003
  • Day, I.N.M. (editor) Book ‘Molecular Genetic Epidemiology – A Laboratory Perspective’ Cambridge, Springer-Verlag, Berlin, Heidelberg, New York 2001 (Cat. CR24)
  • Day, I.N.M.  (editor)  'Genetics of common disease: future therapeutic and diagnostic opportunities,' BIOS Scientific Publishers, Oxford, UK. 1997.(Cat. CR10)

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