Ian Day, MB, PhD, FRCPath

Professor of Molecular and Genetic Epidemiology

Bristol Genetic Epidemiology Laboratories,
Dept. Social Medicine,
University of Bristol,
Canynge Hall,
Whiteladies Road,
Bristol BS8 2PR

 ian.day@bristol.ac.uk
I qualified from the University of Oxford in 1980 with First Class Honours in Physiological Sciences and gained my medical degree with distinction from the University of Cambridge in 1982.  My PhD, undertaken on an MRC Training Fellowship in the Department of Clinical Biochemistry in Cambridge, was in the protein chemistry, immunochemistry and molecular cloning of the protein PGP9.5 and its gene (UCHL1). I accredited in medical biochemistry and completed the MRCPath (in Chemical Pathology) in 1992. From 1992-1995 I held a BHF Intermediate Fellowship at UCLMS and from 1996-2000 was a Lister Institute Fellow. From 1997-2006 I was Professor of Human Genetics at the University of Southampton. Since 1993 much of my research has been in the genetics of cardiovascular diseases and risk factors.

To 2009, I have published over 150 original papers, 50 reviews and chapters, and edited 4 books. I have had almost continuous UK research funding from MRC since 1984 and BHF since 1992 and numerous other funding support ranging from building, JREI, SRIF and other infrastructure awards, to a range of focused project grants. I was head of the Division of Human Genetics (~150 staff and students) in Southampton Medical School for 6 years, where I also ran a group of 15-25 researchers for 9 years. I was head of the postgraduate school of Southampton Medical School for 3 years. I have also had experience of patents, IP and a small spin-out company. I have taught medical biochemistry and genetics at BM, BSc, MSc and PhD/MD levels. I served on BHF project grants panel for 4 years, am a member of MRC College of Experts, have served on UK Foresight panel and EU funding planning panels, am a member of numerous genetics advisory committees and also the MRC DNA Banking Network Oversight Committee, I am reviews editor for Human Genetics and on the editorial board of Human Mutation. For the past decade I have been fully and continuously engaged with clinical, laboratory and statistical aspects of genetic epidemiological population and family research studies and recognise the syntheses of systems biology and hypothesis driven research and of combining technologies effectively into biomedical and translational research.

Since 2007 I have been Deputy Director of the MRC Centre (Causal Analysis in Translational Epidemiology) at the University of Bristol. In addition to Bristol Gnetic Epidemiology Laboratories, I also lead (since 2009) an MRC funded doctoral training programme in Systems Biomedicine (mathematical, statistical and computational approaches to medical research). I am a visiting professor at King Saud University, Riyadh, Saudi Arabia (invited 2010). I have been an external examiner for an MSc in Molecular Diagnostics (University of Nottingham, 2007-2009), for Final MB Clinical Pathology (University of Cambridge, 2007-2010) and for MRCPath (Genetics, 1997-present).

Publications

Original Papers
  1. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, [+99 co-authors], Day IN, [+213 co-authors], Meigs JB, Groop L, Boehnke M, McCarthy MI, Florez JC, Barroso I. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010 Feb;42(2):105-16. Epub 2010 Jan 17.
  2. Gaunt TR, Rodriguez S, Guthrie PA, Day IN. An expectation-maximization program for determining allelic spectrum from CNV data (CoNVEM): insights into population allelic architecture and its mutational history. Hum Mutat. 2010 Jan 14; [Epub ahead of print]
  3. Day IN. dbSNP in the detail and copy number complexities. Hum Mutat. 2010 Jan;31(1):2-4.
  4. Talmud PJ, Drenos F, Shah S, Shah T, Palmen J, Verzilli C, Gaunt TR, Pallas J, Lovering R, Li K, Casas JP, Sofat R, Kumari M, Rodriguez S, Johnson T, Newhouse SJ, Dominiczak A, Samani NJ, Caulfield M, Sever P, Stanton A, Shields DC, Padmanabhan S, Melander O, Hastie C, Delles C, Ebrahim S, Marmot MG, Smith GD, Lawlor DA, Munroe PB, Day IN, Kivimaki M, Whittaker J, Humphries SE, Hingorani AD; ASCOT investigators; NORDIL investigators; BRIGHT Consortium. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. Am J Hum Genet. 2009 Nov;85(5):628-42.
  5. Day IN, Thompson RJ. UCHL1 (PGP 9.5): Neuronal biomarker and ubiquitin system protein. Prog Neurobiol. 2009 Oct 30; [Epub ahead of print]
  6. Chen L, Davey Smith G, Evans DM, Cox A, Lawlor DA, Donovan J, Yuan W, Day IN, Martin RM, Lane A, Rodriguez S, Davis M, Zuccolo L, Collin SM, Hamdy F, Neal D, Lewis SJ. Genetic variants in the vitamin d receptor are associated with advanced prostate cancer at diagnosis: findings from the prostate testing for cancer and treatment study and a systematic review. Cancer Epidemiol Biomarkers Prev. 2009 Nov;18(11):2874-81. Epub 2009 Oct 27.
  7. Lindgren CM, Heid IM, Randall JC, Lamina C, Steinthorsdottir V, Qi L, Speliotes EK, Thorleifsson G, Willer CJ, Herrera BM, Jackson AU, Lim N, Scheet P, Soranzo N, Amin N, Aulchenko YS, Chambers JC, Drong A, Luan J, Lyon HN, Rivadeneira F, Sanna S, Timpson NJ, Zillikens MC, Zhao JH, Almgren P, Bandinelli S, Bennett AJ, Bergman RN, Bonnycastle LL, Bumpstead SJ, Chanock SJ, Cherkas L, Chines P, Coin L, Cooper C, Crawford G, Doering A, Dominiczak A, Doney AS, Ebrahim S, Elliott P, Erdos MR, Estrada K, Ferrucci L, Fischer G, Forouhi NG, Gieger C, Grallert H, Groves CJ, Grundy S, Guiducci C, Hadley D, Hamsten A, Havulinna AS, Hofman A, Holle R, Holloway JW, Illig T, Isomaa B, Jacobs LC, Jameson K, Jousilahti P, Karpe F, Kuusisto J, Laitinen J, Lathrop GM, Lawlor DA, Mangino M, McArdle WL, Meitinger T, Morken MA, Morris AP, Munroe P, Narisu N, Nordstrom A, Nordstrom P, Oostra BA, Palmer CN, Payne F, Peden JF, Prokopenko I, Renstrom F, Ruokonen A, Salomaa V, Sandhu MS, Scott LJ, Scuteri A, Silander K, Song K, Yuan X, Stringham HM, Swift AJ, Tuomi T, Uda M, Vollenweider P, Waeber G, Wallace C, Walters GB, Weedon MN; Wellcome Trust Case Control Consortium; Witteman JC, Zhang C, Zhang W, Caulfield MJ, Collins FS, Davey Smith G, Day IN, Franks PW, Hattersley AT, Hu FB, Jarvelin MR, Kong A, Kooner JS, Laakso M, Lakatta E, Mooser V, Morris AD, Peltonen L, Samani NJ, Spector TD, Strachan DP, Tanaka T, Tuomilehto J, Uitterlinden AG, van Duijn CM, Wareham NJ, Hugh Watkins; Procardis Consortia; Waterworth DM, Boehnke M, Deloukas P, Groop L, Hunter DJ, Thorsteinsdottir U, Schlessinger D, Wichmann HE, Frayling TM, Abecasis GR, Hirschhorn JN, Loos RJ, Stefansson K, Mohlke KL, Barroso I, McCarthy MI; Giant Consortium. Genome-wide association scan meta-analysis identifies three Loci influencing adiposity and fat distribution. PLoS Genet. 2009 Jun;5(6):e1000508. Epub 2009 Jun 26.
  8. Rodriguez S, Hall AJ, Granell R, McLean WH, Irvine AD, Palmer CN, Smith GD, Henderson J, Day IN. Carrier status for the common R501X and 2282del4 filaggrin mutations is not associated with hearing phenotypes in 5,377 children from the ALSPAC cohort. PLoS One. 2009 Jun 3;4(6):e5784.
  9. Dennison EM, Syddall HE, Jameson KA, Sayer AA, Gaunt TR, Rodriguez S, Day IN, Cooper C, Lips MA; Hertfordshire Cohort Study Group. A study of relationships between single nucleotide polymorphisms from the growth hormone-insulin-like growth factor axis and bone mass: the Hertfordshire cohort study. J Rheumatol. 2009 Jul;36(7):1520-6. Epub 2009 Jun 1.
  10. Shugart YY, Chen L, Day IN, Lewis SJ, Timpson NJ, Yuan W, Abdollahi MR, Ring SM, Ebrahim S, Golding J, Lawlor DA, Davey-Smith G. Two British women studies replicated the association between the Val66Met polymorphism in the brain-derived neurotrophic factor (BDNF) and BMI. Eur J Hum Genet. 2009 Aug;17(8):1050-5. Epub 2009 Feb 11.
  11. Rodriguez S, Gaunt TR, Day IN. Hardy-Weinberg equilibrium testing of biological ascertainment for Mendelian randomization studies. Am J Epidemiol. 2009 Feb 15;169(4):505-14. Epub 2009 Jan 6.
  12. Smith GD, Lawlor DA, Timpson NJ, Baban J, Kiessling M, Day IN, Ebrahim S. Lactase persistence-related genetic variant: population substructure and health outcomes. Eur J Hum Genet. 2009 Mar;17(3):357-67. Epub 2008 Sep 17.
  13. Lawlor DA, Harbord RM, Timpson NJ, Lowe GD, Rumley A, Gaunt TR, Baker I, Yarnell JW, Kivimaki M, Kumari M, Norman PE, Jamrozik K, Hankey GJ, Almeida OP, Flicker L, Warrington N, Marmot MG, Ben-Shlomo Y, Palmer LJ, Day IN, Ebrahim S, Smith GD. The association of C-reactive protein and CRP genotype with coronary heart disease: findings from five studies with 4,610 cases amongst 18,637 participants. PLoS One. 2008 Aug 20;3(8):e3011.
  14. Loos RJ, Lindgren CM, Li S, Wheeler E, Zhao JH, Prokopenko I, Inouye M, Freathy RM, Attwood AP, Beckmann JS, Berndt SI; Prostate, Lung, Colorectal, and Ovarian (PLCO) Cancer Screening Trial; Jacobs KB, Chanock SJ, Hayes RB, Bergmann S, Bennett AJ, Bingham SA, Bochud M, Brown M, Cauchi S, Connell JM, Cooper C, Smith GD, Day I, Dina C, De S, Dermitzakis ET, Doney AS, Elliott KS, Elliott P, Evans DM, Sadaf Farooqi I, Froguel P, Ghori J, Groves CJ, Gwilliam R, Hadley D, Hall AS, Hattersley AT, Hebebrand J, Heid IM; KORA; Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Herrera B, Hinney A, Hunt SE, Jarvelin MR, Johnson T, Jolley JD, Karpe F, Keniry A, Khaw KT, Luben RN, Mangino M, Marchini J, McArdle WL, McGinnis R, Meyre D, Munroe PB, Morris AD, Ness AR, Neville MJ, Nica AC, Ong KK, O'Rahilly S, Owen KR, Palmer CN, Papadakis K, Potter S, Pouta A, Qi L; Nurses' Health Study; Randall JC, Rayner NW, Ring SM, Sandhu MS, Scherag A, Sims MA, Song K, Soranzo N, Speliotes EK; Diabetes Genetics Initiative; Syddall HE, Teichmann SA, Timpson NJ, Tobias JH, Uda M; SardiNIA Study; Vogel CI, Wallace C, Waterworth DM, Weedon MN; Wellcome Trust Case Control Consortium; Willer CJ; FUSION; Wraight, Yuan X, Zeggini E, Hirschhorn JN, Strachan DP, Ouwehand WH, Caulfield MJ, Samani NJ, Frayling TM, Vollenweider P, Waeber G, Mooser V, Deloukas P, McCarthy MI, Wareham NJ, Barroso I, Jacobs KB, Chanock SJ, Hayes RB, Lamina C, Gieger C, Illig T, Meitinger T, Wichmann HE, Kraft P, Hankinson SE, Hunter DJ, Hu FB, Lyon HN, Voight BF, Ridderstrale M, Groop L, Scheet P, Sanna S, Abecasis GR, Albai G, Nagaraja R, Schlessinger D, Jackson AU, Tuomilehto J, Collins FS, Boehnke M, Mohlke KL. Common variants near MC4R are associated with fat mass, weight and risk of obesity. Nat Genet. 2008 Jun;40(6):768-75. Epub 2008 May 4.
  15. Chen L, Lawlor DA, Lewis SJ, Yuan W, Abdollahi MR, Timpson NJ, Day IN, Ebrahim S, Smith GD, Shugart YY. Genetic association study of BDNF in depression: finding from two cohort studies and a meta-analysis. Am J Med Genet B Neuropsychiatr Genet. 2008 Sep 5;147B(6):814-21.
  16. Smith GD, Lawlor DA, Harbord R, Timpson N, Day I, Ebrahim S. Clustered environments and randomized genes: a fundamental distinction between conventional and genetic epidemiology. PLoS Med. 2007 Dec;4(12):e352.
  17. Sonnenberg S, Shearman CP, Baxter S, Morris GE, Cumming DV, Montgomery HE, Rose-Zerilli MJ, Day IN. Level of ex vivo interleukin 6 expression in human peripheral fat compared with other tissues. Eur J Vasc Endovasc Surg. 2008 Mar;35(3):314-9. Epub 2007 Dec 26.
  18. Abdollahi MR, Huang S, Rodriguez S, Guthrie PA, Smith GD, Ebrahim S, Lawlor DA, Day IN, Gaunt TR. Homogeneous assay of rs4343, an ACE I/D proxy, and an analysis in the British Women's Heart and Health Study (BWHHS). Dis Markers. 2008;24(1):11-7.
  19. Gaunt TR, Rodriguez S, Day IN. Cubic exact solutions for the estimation of pairwise haplotype frequencies: implications for linkage disequilibrium analyses and a web tool 'CubeX'. BMC Bioinformatics. 2007 Nov 2;8:428.
  20. Publication Types: Comment Letter Rodriguez S, Gaunt TR, Vorechovsky I, Kralovicova J, Wood PJ, Day IN. Diabetes. 2007 Sep;56(9):e16; author reply e17.
  21. Timpson NJ, Heron J, Day IN, Ring SM, Bartoshuk LM, Horwood J, Emmett P, Davey-Smith G. Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children. BMC Genet. 2007 Jul 28;8:51.
  22. Rodriguez S, Gaunt TR, Day IN. Molecular genetics of human growth hormone, insulin-like growth factors and their pathways in common disease. Hum Genet. 2007 Aug;122(1):1-21. Epub 2007 May 30.
  23. Huang S, Chen XH, Payne JR, Pennell DJ, Gohlke P, Smith MJ, Day IN, Montgomery HE, Gaunt TR. Haplotype of growth hormone and angiotensin I-converting enzyme genes, serum angiotensin I-converting enzyme and ventricular growth: pathway inference in pharmacogenetics. Pharmacogenet Genomics. 2007 Apr;17(4):291-4.
  24. Kyriakou T, Pontefract DE, Viturro E, Hodgkinson CP, Laxton RC, Bogari N, Cooper G, Davies M, Giblett J, Day IN, Simpson IA, Albrecht C, Ye S. Functional polymorphism in ABCA1 influences age of symptom onset in coronary artery disease patients. Hum Mol Genet. 2007 Jun 15;16(12):1412-22. Epub 2007 Apr 5.
  25. Ebrahim S, Lawlor DA, Shlomo YB, Timpson N, Harbord R, Christensen M, Baban J, Kiessling M, Day I, Gaunt T, Davey Smith G. Alcohol dehydrogenase type 1C (ADH1C) variants, alcohol consumption traits, HDL-cholesterol and risk of coronary heart disease in women and men: British Women's Heart and Health Study and Caerphilly cohorts. Atherosclerosis. 2008 Feb;196(2):871-8. Epub 2007 Mar 26.
  26. Lips MA, Syddall HE, Gaunt TR, Rodriguez S, Day IN, Cooper C, Dennison EM; Southampton Genetic Epidemiology Research Group. Interaction between birthweight and polymorphism in the calcium-sensing receptor gene in determination of adult bone mass: the Hertfordshire cohort study. J Rheumatol. 2007 Apr;34(4):769-75. Epub 2007 Feb 15.
  27. Abdollahi MR, Lewis RM, Gaunt TR, Cumming DV, Rodriguez S, Rose-Zerilli M, Collins AR, Syddall HE, Howell WM, Cooper C, Godfrey KM, Cameron IT, Day IN. Quantitated transcript haplotypes (QTH) of AGTR1, reduced abundance of mRNA haplotypes containing 1166C (rs5186:A>C), and relevance to metabolic syndrome traits. Hum Mutat. 2007 Apr;28(4):365-73.
  28. Lawlor DA, Day IN, Gaunt TR, Hinks LJ, Timpson N, Ebrahim S, Davey Smith G. The association of the paraoxonase (PON1) Q192R polymorphism with depression in older women: findings from the British Women's Heart and Health Study. J Epidemiol Community Health. 2007 Jan;61(1):85-7.
  29. Alharbi KK, Spanakis E, Tan K, Smith MJ, Aldahmesh MA, O'Dell SD, Sayer AA, Lawlor DA, Ebrahim S, Davey Smith G, O'Rahilly S, Farooqi S, Cooper C, Phillips DI, Day IN. Prevalence and functionality of paucimorphic and private MC4R mutations in a large, unselected European British population, scanned by meltMADGE. Hum Mutat. 2007 Mar;28(3):294-302.
  30. Zhang W, Maniatis N, Rodriguez S, Miller GJ, Day IN, Gaunt TR, Collins A, Morton NE. Refined association mapping for a quantitative trait: weight in the H19-IGF2-INS-TH region. Ann Hum Genet. 2006 Nov;70(Pt 6):848-56.
  31. Gunnell D, Lewis S, Wilkinson J, Georgieva L, Davey GS, Day IN, Holly JM, O'Donovan MC, Owen MJ, Kirov G, Zammit S. IGF1, growth pathway polymorphisms and schizophrenia: a pooling study. Am J Med Genet B Neuropsychiatr Genet. 2007 Jan 5;144B(1):117-20.
  32. Fawcett KA, Wareham NJ, Luan J, Syddall H, Cooper C, O'Rahilly S, Day IN, Sandhu MS, Barroso I. PARL Leu262Val is not associated with fasting insulin levels in UK populations. Diabetologia. 2006 Nov;49(11):2649-52. Epub 2006 Sep 21.
  33. Johnstone E, Benowitz N, Cargill A, Jacob R, Hinks L, Day I, Murphy M, Walton R. Determinants of the rate of nicotine metabolism and effects on smoking behavior. Clin Pharmacol Ther. 2006 Oct;80(4):319-30.
  34. Day IN, Rodriguez S, Kralovicova J, Wood PJ, Vorechovsky I, Gaunt TR. Questioning INS VNTR role in obesity and diabetes: subclasses tag IGF2-INS-TH haplotypes; and -23HphI as a STEP (splicing and translational efficiency polymorphism). Physiol Genomics. 2006 Dec 13;28(1):113. Epub 2006 Aug 1.
  35. Huang S, Chen XH, Day IN. Combination of 768-well microplate array diagonal gel electrophoresis with duplex PCR of X and Y chromosome markers for quality control of epidemiological DNA banks. Electrophoresis. 2006 Aug;27(15):3038-41.
  36. Abdollahi MR, Guthrie PA, Smith GD, Lawlor DA, Ebrahim S, Day IN. Integrated single-label liquid-phase assay of APOE codons 112 and 158 and a lipoprotein study in British women. Clin Chem. 2006 Jul;52(7):1420-3. Epub 2006 Apr 27.
  37. Gaunt TR, Rodriguez S, Zapata C, Day IN. MIDAS: software for analysis and visualisation of interallelic disequilibrium between multiallelic markers. BMC Bioinformatics. 2006 Apr 27;7:227.
  38. Lawlor DA, Gaunt TR, Hinks LJ, Davey Smith G, Timpson N, Day IN, Ebrahim S. The association of the PON1 Q192R polymorphism with complications and outcomes of pregnancy: findings from the British Women's Heart and Health cohort study. Paediatr Perinat Epidemiol. 2006 May;20(3):244-50.
  39. Lawlor DA, Timpson N, Ebrahim S, Day IN, Smith GD. The association of oestrogen receptor alpha-haplotypes with cardiovascular risk factors in the British Women's Heart and Health Study. Eur Heart J. 2006 Jul;27(13):1597-604. Epub 2006 Mar 21.
  40. Christensen MB, Lawlor DA, Gaunt TR, Howell WM, Davey Smith G, Ebrahim S, Day IN. Genotype of galectin 2 (LGALS2) is associated with insulin-glucose profile in the British Women's Heart and Health Study. Diabetologia. 2006 Apr;49(4):673-7. Epub 2006 Feb 9.
  41. Lewis SJ, Lawlor DA, Davey Smith G, Araya R, Timpson N, Day IN, Ebrahim S. The thermolabile variant of MTHFR is associated with depression in the British Women's Heart and Health Study and a meta-analysis. Mol Psychiatry. 2006 Apr;11(4):352-60.
  42. Kralovicova J, Gaunt TR, Rodriguez S, Wood PJ, Day IN, Vorechovsky I. Variants in the human insulin gene that affect pre-mRNA splicing: is -23HphI a functional single nucleotide polymorphism at IDDM2? Diabetes. 2006 Jan;55(1):260-4.
  43. Rodriguez S, Huang S, Chen XH, Gaunt TR, Syddall HE, Gilg JA, Miller GJ, Cooper CC, Cook DG, Whincup PH, Day IN. A study of TH01 and IGF2-INS-TH haplotypes in relation to smoking initiation in three independent surveys. Pharmacogenet Genomics. 2006 Jan;16(1):15-23.
  44. Timpson NJ, Lawlor DA, Harbord RM, Gaunt TR, Day IN, Palmer LJ, Hattersley AT, Ebrahim S, Lowe GD, Rumley A, Davey Smith G. C-reactive protein and its role in metabolic syndrome: mendelian randomisation study. Lancet. 2005 Dec 3;366(9501):1954-9.
  45. Huang S, Cook DG, Hinks LJ, Chen XH, Ye S, Gilg JA, Jarvis MJ, Whincup PH, Day IN. CYP2A6, MAOA, DBH, DRD4, and 5HT2A genotypes, smoking behaviour and cotinine levels in 1518 UK adolescents. Pharmacogenet Genomics. 2005 Dec;15(12):839-50.
  46. Rodriguez S, Gaunt TR, Dennison E, Chen XH, Syddall HE, Phillips DI, Cooper C, Day IN. Replication of IGF2-INS-TH*5 haplotype effect on obesity in older men and study of related phenotypes. Eur J Hum Genet. 2006 Jan;14(1):109-16.
  47. Lei H, Day IN, Vorechovsky I. Exonization of AluYa5 in the human ACE gene requires mutations in both 3' and 5' splice sites and is facilitated by a conserved splicing enhancer. Nucleic Acids Res. 2005 Jul 14;33(12):3897-906. Print 2005.
  48. Alharbi KK, Aldahmesh MA, Spanakis E, Haddad L, Whittall RA, Chen XH, Rassoulian H, Smith MJ, Sillibourne J, Ball NJ, Graham NJ, Briggs PJ, Simpson IA, Phillips DI, Lawlor DA, Ye S, Humphries SE, Cooper C, Smith GD, Ebrahim S, Eccles DM, Day IN. Mutation scanning by meltMADGE: validations using BRCA1 and LDLR, and demonstration of the potential to identify severe, moderate, silent, rare, and paucimorphic mutations in the general population. Genome Res. 2005 Jul;15(7):967-77.
  49. Smith MJ, Pante-de-Sousa G, Alharbi KK, Chen XH, Day IN, Fox KR. Combination of His-tagged T4 endonuclease VII with microplate array diagonal gel electrophoresis for high-throughput mutation scanning. Clin Chem. 2005 Jun;51(6):1043-6.
  50. Timpson NJ, Christensen M, Lawlor DA, Gaunt TR, Day IN, Ebrahim S, Davey Smith G. TAS2R38 (phenylthiocarbamide) haplotypes, coronary heart disease traits, and eating behavior in the British Women's Heart and Health Study. Am J Clin Nutr. 2005 May;81(5):1005-11.
  51. Abdollahi MR, Gaunt TR, Syddall HE, Cooper C, Phillips DI, Ye S, Day IN. Angiotensin II type I receptor gene polymorphism: anthropometric and metabolic syndrome traits. J Med Genet. 2005 May;42(5):396-401.
  52. Holmes C, Ballard C, Lehmann D, David Smith A, Beaumont H, Day IN, Nadeem Khan M, Lovestone S, McCulley M, Morris CM, Munoz DG, O'Brien K, Russ C, Del Ser T, Warden D. Rate of progression of cognitive decline in Alzheimer's disease: effect of butyrylcholinesterase K gene variation. J Neurol Neurosurg Psychiatry. 2005 May;76(5):640-3.
  53. Davey Smith G, Lawlor DA, Harbord R, Timpson N, Rumley A, Lowe GD, Day IN, Ebrahim S. Association of C-reactive protein with blood pressure and hypertension: life course confounding and mendelian randomization tests of causality. Arterioscler Thromb Vasc Biol. 2005 May;25(5):1051-6. Epub 2005 Feb 24.
  54. Rodriguez S, Chen XH, Miller GJ, Day IN. Non-recombining chromosome Y haplogroups and centromeric HindIII RFLP in relation to blood pressure in 2,743 middle-aged Caucasian men from the UK. Hum Genet. 2005 Mar;116(4):311-8. Epub 2005 Jan 27.
  55. Day IN, Chen XH, Gaunt TR, King TH, Voropanov A, Ye S, Rodriguez S, Syddall HE, Sayer AA, Dennison EM, Tabassum F, Barker DJ, Cooper C, Phillips DI. Late life metabolic syndrome, early growth, and common polymorphism in the growth hormone and placental lactogen gene cluster. J Clin Endocrinol Metab. 2004 Nov;89(11):5569-76.
  56. Dennison EM, Syddall HE, Rodriguez S, Voropanov A, Day IN, Cooper C; Southampton Genetic Epidemiology Research Group. Polymorphism in the growth hormone gene, weight in infancy, and adult bone mass. J Clin Endocrinol Metab. 2004 Oct;89(10):4898-903.
  57. Chen XH, Rodriguez S, Hawe E, Talmud PJ, Miller GJ, Underhill P, Humphries SE, Day IN. Evidence of admixture from haplotyping in an epidemiological study of UK Caucasian males: implications for association analyses. Hum Hered. 2004;57(3):142-55.
  58. Lawlor DA, Day IN, Gaunt TR, Hinks LJ, Briggs PJ, Kiessling M, Timpson N, Smith GD, Ebrahim S. The association of the PON1 Q192R polymorphism with coronary heart disease: findings from the British Women's Heart and Health cohort study and a meta-analysis. BMC Genet. 2004 Jun 23;5:17.
  59. Rodriguez S, Chen XH, Day IN. Typing dinucleotide repeat loci using microplate array diagonal gel electrophoresis: proof of principle. Electrophoresis. 2004 Apr;25(7-8):975-9.
  60. Rodriguez S, Gaunt TR, O'Dell SD, Chen XH, Gu D, Hawe E, Miller GJ, Humphries SE, Day IN. Haplotypic analyses of the IGF2-INS-TH gene cluster in relation to cardiovascular risk traits. Hum Mol Genet. 2004 Apr 1;13(7):715-25. Epub 2004 Jan 28.
  61. McCulley MC, Day IN, Holmes C. Association between interleukin 1-beta promoter (-511) polymorphism and depressive symptoms in Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2004 Jan 1;124B(1):50-3.
  62. Marchbanks RM, Ryan M, Day IN, Owen M, McGuffin P, Whatley SA. A mitochondrial DNA sequence variant associated with schizophrenia and oxidative stress. Schizophr Res. 2003 Dec 1;65(1):33-8.
  63. Ye S, Dhillon S, Seear R, Dunleavey L, Day LB, Bannister W, Day IN, Simpson I. Epistatic interaction between variations in the angiotensin I converting enzyme and angiotensin II type 1 receptor genes in relation to extent of coronary atherosclerosis. Heart. 2003 Oct;89(10):1195-9.
  64. Beyzade S, Zhang S, Wong YK, Day IN, Eriksson P, Ye S. Influences of matrix metalloproteinase-3 gene variation on extent of coronary atherosclerosis and risk of myocardial infarction. J Am Coll Cardiol. 2003 Jun 18;41(12):2130-7.
  65. Zhang B, Fugleholm K, Day LB, Ye S, Weller RO, Day IN. Molecular pathogenesis of subarachnoid haemorrhage. Int J Biochem Cell Biol. 2003 Sep;35(9):1341-60.
  66. Ye S, Dunleavey L, Bannister W, Day LB, Tapper W, Collins AR, Day IN, Simpson I; Southampton Atherosclerosis Study. Independent effects of the -219 G>T and epsilon 2/ epsilon 3/ epsilon 4 polymorphisms in the apolipoprotein E gene on coronary artery disease: the Southampton Atherosclerosis Study. Eur J Hum Genet. 2003 Jun;11(6):437-43.
  67. Gaunt TR, Hinks LJ, Rassoulian H, Day IN. Manual 768 or 384 well microplate gel 'dry' electrophoresis for PCR checking and SNP genotyping. Nucleic Acids Res. 2003 May 1;31(9):e48.
  68. Zhang B, Ye S, Sayer AA, Hammans SR, Adio S, Hinks LJ, Smythe PJ, Groot D, Cooper C, Day IN. A study of mitochondrial DNA mutations in peripheral lymphocytes in an aging cohort. Biochem Soc Trans. 2003 Apr;31(2):444-6.
  69. Sayer AA, Syddall H, O'Dell SD, Chen XH, Briggs PJ, Briggs R, Day IN, Cooper C. Polymorphism of the IGF2 gene, birth weight and grip strength in adult men. Age Ageing. 2002 Nov;31(6):468-70.
  70. O'Dell SD, Syddall HE, Sayer AA, Cooper C, Fall CH, Dennison EM, Phillips DI, Gaunt TR, Briggs PJ, Day IN. Null mutation in human ciliary neurotrophic factor gene confers higher body mass index in males. Eur J Hum Genet. 2002 Nov;10(11):749-52.
  71. Day IN, King TH, Chen XH, Voropanov AM, Ye S, Syddall HE, Sayer AA, Cooper C, Barker DJ, Phillips DI. Insulin-like growth factor-I genotype and birthweight. Lancet. 2002 Sep 21;360(9337):945; author reply 945-6.
  72. Chen XH, O'Dell SD, Day IN. Microplate array diagonal gel electrophoresis for cohort studies of microsatellite loci. Biotechniques. 2002 May;32(5):1080-2, 1084, 1086 passim.
  73. Gu D, O'Dell SD, Chen XH, Miller GJ, Day IN. Evidence of multiple causal sites affecting weight in the IGF2-INS-TH region of human chromosome 11. Hum Genet. 2002 Feb;110(2):173-81. Epub 2002 Jan 24.
  74. Zhang J, Day IN, Byrne CD. A novel medium throughput quantitative competitive PCR technology to simultaneously measure mRNA levels from multiple genes. Nucleic Acids Res. 2002 Mar 1;30(5):e20.
  75. Day IN, Wilson DI. Science, medicine, and the future: Genetics and cardiovascular risk. BMJ. 2001 Dec 15;323(7326):1409-12.
  76. Zhang B, Dhillon S, Geary I, Howell WM, Iannotti F, Day IN, Ye S. Polymorphisms in matrix metalloproteinase-1, -3, -9, and -12 genes in relation to subarachnoid hemorrhage. Stroke. 2001 Sep;32(9):2198-202.
  77. Ye S, Dhillon S, Ke X, Collins AR, Day IN. An efficient procedure for genotyping single nucleotide polymorphisms. Nucleic Acids Res. 2001 Sep 1;29(17):E88-8.
  78. Day IN, Gu D, Ganderton RH, Spanakis E, Ye S. Epidemiology and the genetic basis of disease. Int J Epidemiol. 2001 Aug;30(4):661-7.
  79. Dennison EM, Arden NK, Keen RW, Syddall H, Day IN, Spector TD, Cooper C. Birthweight, vitamin D receptor genotype and the programming of osteoporosis. Paediatr Perinat Epidemiol. 2001 Jul;15(3):211-9.
  80. Humphries SE, Talmud PJ, Hawe E, Bolla M, Day IN, Miller GJ. Apolipoprotein E4 and coronary heart disease in middle-aged men who smoke: a prospective study. Lancet. 2001 Jul 14;358(9276):115-9.
  81. Gaunt TR, Cooper JA, Miller GJ, Day IN, O'Dell SD. Positive associations between single nucleotide polymorphisms in the IGF2 gene region and body mass index in adult males. Hum Mol Genet. 2001 Jul 1;10(14):1491-501.
  82. Zhang S, Day IN, Ye S. Microarray analysis of nicotine-induced changes in gene expression in endothelial cells. Physiol Genomics. 2001 Apr 27;5(4):187-92.
  83. Gu DF, Hinks LJ, Morton NE, Day IN. The use of long PCR to confirm three common alleles at the CYP2A6 locus and the relationship between genotype and smoking habit. Ann Hum Genet. 2000 Sep;64(Pt 5):383-90.
  84. Holloway JW, Ye S, Day IN. Tools for molecular genetic epidemiology: a comparison of MADGE methodology with other systems. Biotechnol Genet Eng Rev. 2000;17:71-88.
  85. Ye S, Dhillon S, Turner SJ, Bateman AC, Theaker JM, Pickering RM, Day I, Howell WM. Invasiveness of cutaneous malignant melanoma is influenced by matrix metalloproteinase 1 gene polymorphism. Cancer Res. 2001 Feb 15;61(4):1296-8.
  86. Zhang S, Day I, Ye S. Nicotine induced changes in gene expression by human coronary artery endothelial cells. Atherosclerosis. 2001 Feb 1;154(2):277-83.
  87. O'Dell SD, Gaunt TR, Day IN. SNP genotyping by combination of 192-well MADGE, ARMS and computerized gel image analysis. Biotechniques. 2000 Sep;29(3):500-4, 505-6.
  88. O'Dell SD, Chen X, Day IN. Higher resolution microplate array diagonal gel electrophoresis: application to a multiallelic minisatellite. Hum Mutat. 2000;15(6):565-76.
  89. Heath KE, Day IN, Humphries SE. Universal primer quantitative fluorescent multiplex (UPQFM) PCR: a method to detect major and minor rearrangements of the low density lipoprotein receptor gene. J Med Genet. 2000 Apr;37(4):272-80.
  90. Voropanov AM, Day IN. Elimination of dumbbell bands and enhancement of resolution in MADGE using delayed start electrophoresis. Biotechniques. 2000 Jan;28(1):32-4.
  91. Humphries SE, Luong LA, Montgomery HE, Day IN, Mohamed-Ali V, Yudkin JS. Gene-environment interaction in the determination of levels of plasma fibrinogen. Thromb Haemost. 1999 Aug;82(2):818-25.
  92. O'Dell SD, Bujac SR, Miller GJ, Day IN. Associations of IGF2 ApaI RFLP and INS VNTR class I allele size with obesity. Eur J Hum Genet. 1999 Oct-Nov;7(7):821-7.
  93. Holloway JW, Beghe B, Turner S, Hinks LJ, Day IN, Howell WM. Comparison of three methods for single nucleotide polymorphism typing for DNA bank studies: sequence-specific oligonucleotide probe hybridisation, TaqMan liquid phase hybridisation, and microplate array diagonal gel electrophoresis (MADGE). Hum Mutat. 1999;14(4):340-7.
  94. Day IN, Spanakis E, Chen X, O'Dell SD. Microplate array diagonal gel electrophoresis for mutation research in DNA banks. Electrophoresis. 1999 Jun;20(6):1250-7.
  95. Haddad L, Day IN, Hunt S, Williams RR, Humphries SE, Hopkins PN. Evidence for a third genetic locus causing familial hypercholesterolemia. A non-LDLR, non-APOB kindred. J Lipid Res. 1999 Jun;40(6):1113-22.
  96. Rosenberg W, Howell M, Roderick P, Eccles D, Day I. Hereditary haemochromatosis should be more widely known about. BMJ. 1999 May 29;318(7196):1486-7.
  97. Day IN, O'Dell SD, Spanakis E, Weavind GP. Microplate array diagonal gel electrophoresis (MADGE), CpG-PCR and temporal thermal ramp-MADGE (Melt-MADGE) for single nucleotide analyses in populations. Genet Anal. 1999 Feb;14(5-6):197-204.
  98. O'Dell SD, Day IN. Insulin-like growth factor II (IGF-II). Int J Biochem Cell Biol. 1998 Jul;30(7):767-71.
  99. Lee WK, Haddad L, Macleod MJ, Dorrance AM, Wilson DJ, Gaffney D, Dominiczak MH, Packard CJ, Day IN, Humphries SE, Dominiczak AF. Identification of a common low density lipoprotein receptor mutation (C163Y) in the west of Scotland. J Med Genet. 1998 Jul;35(7):573-8.
  100. Day IN, Spanakis E, Palamand D, Weavind GP, O'Dell SD. Microplate-array diagonal-gel electrophoresis (MADGE) and melt-MADGE: tools for molecular-genetic epidemiology. Trends Biotechnol. 1998 Jul;16(7):287-90.
  101. De Oliveira e Silva ER, Haddad L, Kwiterovich PO Jr, Humphries SE, Day IN. Applicability of LDLR flanking microsatellite polymorphisms for prenatal diagnosis of homozygous state for familial hypercholesterolemia. Clin Genet. 1998 May;53(5):375-8.
  102. Wilson DJ, Gahan M, Haddad L, Heath K, Whittall RA, Williams RR, Humphries SE, Day IN. A World Wide Web site for low-density lipoprotein receptor gene mutations in familial hypercholesterolemia: sequence-based, tabular, and direct submission data handling. Am J Cardiol. 1998 Jun 15;81(12):1509-11.
  103. O'Dell SD, Bolla MK, Miller GJ, Cooper JA, Humphries SE, Day IN. W64R mutation in beta-3-adrenergic receptor gene and weight in a large population sample. Int J Obes Relat Metab Disord. 1998 Apr;22(4):377-9.
  104. Bolla MK, Miller GJ, Yellon DM, Evans A, Luc G, Cambou JP, Arveiler D, Cambien F, Latchman DS, Humphries SE, Day IN. Analysis of the association of a heat shock protein70-1 gene promoter polymorphism with myocardial infarction and coronary risk traits. Dis Markers. 1998 Feb;13(4):227-35.
  105. O'Dell SD, Wilson DJ, Durrington PN, Humphries SE, Day IN. CpG-PCR combined with sample pooling and mutant enrichment for CpG mutation screening in population studies. Clin Chem. 1998 Jan;44(1):183-5.
  106. Wenham PR, Haddad L, Panarelli M, Ashby JP, Day IN, Giles PD, Humphries SE, Penney MD, Rae PW, Walker SW. Simplified detection of a mutation causing familial hypercholesterolaemia throughout Britain: evidence for an origin in a common distant ancestor. Ann Clin Biochem. 1998 Mar;35 ( Pt 2):226-35.
  107. Traeger-Synodinos J, Mavroidis N, Kanavakis E, Drogari E, Humphries SE, Day IN, Kattamis C, Matsaniotis N. Analysis of low density lipoprotein receptor gene mutations and microsatellite haplotypes in Greek FH heterozygous children: six independent ancestors account for 60% of probands. Hum Genet. 1998 Mar;102(3):343-7.
  108. Haddad L, Day LB, Attwood J, Povey S, Humphries SE, Day IN. Development of a microsatellite-based approach to co-segregation analysis of familial hypercholesterolaemic kindreds. Ann Hum Genet. 1997 Nov;61(Pt 6):497-506.
  109. Austin MA, Talmud PJ, Luong LA, Haddad L, Day IN, Newman B, Edwards KL, Krauss RM, Humphries SE. Candidate-gene studies of the atherogenic lipoprotein phenotype: a sib-pair linkage analysis of DZ women twins. Am J Hum Genet. 1998 Feb;62(2):406-19.
  110. Nissen H, Day LB, Horder M, Humphries SE, Day IN. Denaturing gradient gel electrophoretic analysis of codons 3456-3553 of the apolipoprotein-B gene in 106 type 11a hyperlipoproteinaemic individuals. Ann Clin Biochem. 1998 Jan;35 ( Pt 1):137-9.
  111. O'Dell SD, Miller GJ, Cooper JA, Hindmarsh PC, Pringle PJ, Ford H, Humphries SE, Day IN. Apal polymorphism in insulin-like growth factor II (IGF2) gene and weight in middle-aged males. Int J Obes Relat Metab Disord. 1997 Sep;21(9):822-5.
  112. Humphries SE, Gudnason V, Whittall R, Day IN. Single-strand conformation polymorphism analysis with high throughput modifications, and its use in mutation detection in familial hypercholesterolemia. The IFCC Scientific Division: Committee on Molecular Biology Techniques. J Int Fed Clin Chem. 1997 Dec;9(4):156-61.
  113. Myant NB, Forbes SA, Day IN, Gallagher J. Estimation of the age of the ancestral arginine3500-->glutamine mutation in human apoB-100. Genomics. 1997 Oct 1;45(1):78-87.
  114. Humphries SE, Gudnason V, Whittall R, Day IN. Single-strand conformation polymorphism analysis with high throughput modifications, and its use in mutation detection in familial hypercholesterolemia. International Federation of Clinical Chemistry Scientific Division: Committee on Molecular Biology Techniques. Clin Chem. 1997 Mar;43(3):427-35.
  115. Day IN. Polymerase chain reaction. Br J Hosp Med. 1997 Feb 19-Mar 4;57(4):170-1.
  116. Day IN, Haddad L, O'Dell SD, Day LB, Whittall RA, Humphries SE. Identification of a common low density lipoprotein receptor mutation (R329X) in the south of England: complete linkage disequilibrium with an allele of microsatellite D19S394. J Med Genet. 1997 Feb;34(2):111-6.
  117. Day IN, Whittall RA, O'Dell SD, Haddad L, Bolla MK, Gudnason V, Humphries SE. Spectrum of LDL receptor gene mutations in heterozygous familial hypercholesterolemia. Hum Mutat. 1997;10(2):116-27.
  118. Mavroidis N, Traeger-Synodinos J, Kanavakis E, Drogari E, Matsaniotis N, Humphries SE, Day IN, Kattamis C. A high incidence of mutations in exon 6 of the low-density lipoprotein receptor gene in Greek familial hypercholesterolemia patients, including a novel mutation. Hum Mutat. 1997;9(3):274-6.
  119. Day I, Humphries S. Genetic tests for familial hypercholesterolemia. Nat Biotechnol. 1996 Oct;14(10):1227-8.
  120. Talmud PJ, Tamplin OJ, Heath K, Gaffney D, Day IN, Humphries SE. Rapid testing for three mutations causing familial defective apolipoprotein B100 in 562 patients with familial hypercholesterolaemia. Atherosclerosis. 1996 Aug 23;125(1):135-7.
  121. O'Dell SD, Humphries SE, Day IN. PCR induction of a TaqI restriction site at any CpG dinucleotide using two mismatched primers (CpG-PCR). Genome Res. 1996 Jun;6(6):558-68.
  122. Gudnason V, Day IN, Humphries SE. Use of the single strand conformation polymorphism method for rapid screening for mutations in the low density lipoprotein receptor gene in patients with familial hypercholesterolemia: effect on plasma lipid levels of different classes of mutations. Z Gastroenterol. 1996 Jun;34 Suppl 3:6-8.
  123. Day IN, Humphries SE, Richards S, Norton D, Reid M. High-throughput genotyping using horizontal polyacrylamide gels with wells arranged for microplate array diagonal gel electrophoresis (MADGE). Biotechniques. 1995 Nov;19(5):830-5.
  124. Bolla MK, Haddad L, Humphries SE, Winder AF, Day IN. High-throughput method for determination of apolipoprotein E genotypes with use of restriction digestion analysis by microplate array diagonal gel electrophoresis. Clin Chem. 1995 Nov;41(11):1599-604.
  125. Ganderton RH, Day IN, Briggs RS. Patterns of DNA methylation of the parathyroid hormone-related protein gene in human lung carcinoma. Eur J Cancer. 1995 Sep;31A(10):1697-700.
  126. Day IN, O'Dell SD, Cash ID, Humphries SE, Weavind GP. Electrophoresis for genotyping: temporal thermal gradient gel electrophoresis for profiling of oligonucleotide dissociation. Nucleic Acids Res. 1995 Jul 11;23(13):2404-12.
  127. Whittall R, Gudnason V, Weavind GP, Day LB, Humphries SE, Day IN. Utilities for high throughput use of the single strand conformational polymorphism method: screening of 791 patients with familial hypercholesterolaemia for mutations in exon 3 of the low density lipoprotein receptor gene. J Med Genet. 1995 Jul;32(7):509-15.
  128. Day IN, Whittall R, Gudnason V, Humphries SE. Dried template DNA, dried PCR oligonucleotides and mailing in 96-well plates: LDL receptor gene mutation screening. Biotechniques. 1995 Jun;18(6):981-4.
  129. Schofield JN, Day IN, Thompson RJ, Edwards YH. PGP9.5, a ubiquitin C-terminal hydrolase; pattern of mRNA and protein expression during neural development in the mouse. Brain Res Dev Brain Res. 1995 Apr 18;85(2):229-38.
  130. O'Dell SD, Humphries SE, Day IN. Rapid methods for population-scale analysis for gene polymorphisms: the ACE gene as an example. Br Heart J. 1995 Apr;73(4):368-71.
  131. Gudnason V, Day IN, Humphries SE. Effect on plasma lipid levels of different classes of mutations in the low-density lipoprotein receptor gene in patients with familial hypercholesterolemia. Arterioscler Thromb. 1994 Nov;14(11):1717-22.
  132. Day IN, Humphries SE. Electrophoresis for genotyping: microtiter array diagonal gel electrophoresis on horizontal polyacrylamide gels, hydrolink, or agarose. Anal Biochem. 1994 Nov 1;222(2):389-95.
  133. Laywood A, Whittall R, Gudnason V, Humphries SE, Day IN. Handling of large (300 x 400 mm), thin (0.4 mm) polyacrylamide gels and recovery as dried gels. Biotechniques. 1994 Nov;17(5):850-4.
  134. Quinn GB, Reeves IG, Day IN. Mapping of antigenic sites in human neuron-specific enolase by expression subcloning. Clin Chem. 1994 May;40(5):790-5.
  135. Harrington CR, Quinn GB, Hurt J, Day IN, Wischik CM. Characterisation of an epitope specific to the neuron-specific isoform of human enolase recognised by a monoclonal antibody raised against a synthetic peptide corresponding to the C-terminus of beta/A4-protein. Biochim Biophys Acta. 1993 Oct 3;1158(2):120-8.
  136. Peshavaria M, Day IN. Methylation patterns in the human muscle-specific enolase gene (ENO3). Biochem J. 1993 Jun 15;292 ( Pt 3):701-4.
  137. Day IN, Peshavaria M, Quinn GB. A differential molecular clock in enolase isoprotein evolution. J Mol Evol. 1993 Jun;36(6):599-601.
  138. Day IN. Enolases and PGP9.5 as tissue-specific markers. Biochem Soc Trans. 1992 Aug;20(3):637-42.
  139. Lavender FL, Day IN, Thompson RJ. DNA sequence comparison between human and marsupial genes encoding PGP9.5--a neurone-specific ubiquitin C-terminal hydrolase. Biochem Soc Trans. 1992 Aug;20(3):263S.
  140. Day IN. Analysis of the 5'-AAUAAA motif and its flanking sequence in human RNA: relevance to cDNA library sorting. Gene. 1992 Jan 15;110(2):245-9.
  141. Edwards YH, Fox MF, Povey S, Hinks LJ, Thompson RJ, Day IN. The gene for human neurone specific ubiquitin C-terminal hydrolase (UCHL1, PGP9.5) maps to chromosome 4p14. Ann Hum Genet. 1991 Oct;55(Pt 4):273-8.
  142. Peshavaria M, Day IN. Molecular structure of the human muscle-specific enolase gene (ENO3). Biochem J. 1991 Apr 15;275 ( Pt 2):427-33.
  143. Day IN, Hinks LJ, Thompson RJ. The structure of the human gene encoding protein gene product 9.5 (PGP9.5), a neuron-specific ubiquitin C-terminal hydrolase. Biochem J. 1990 Jun 1;268(2):521-4.
  144. Peshavaria M, Quinn GB, Reeves I, Hinks LJ, Day IN. Molecular biology of the human enolase gene family: nerve (gamma), muscle (beta) and general (alpha) isoforms. Biochem Soc Trans. 1990 Apr;18(2):254-5.
  145. Craig SP, Day IN, Thompson RJ, Craig IW. Localisation of neurone-specific enolase (ENO2) to 12p13. Cytogenet Cell Genet. 1990;54(1-2):71-3.
  146. Peshavaria M, Hinks LJ, Day IN. Structure of human muscle (beta) enolase mRNA and protein deduced from a genomic clone. Nucleic Acids Res. 1989 Nov 11;17(21):8862.
  147. McAleese SM, Dunbar B, Fothergill JE, Hinks LJ, Day IN. Complete amino acid sequence of the neurone-specific gamma isozyme of enolase (NSE) from human brain and comparison with the non-neuronal alpha form (NNE). Eur J Biochem. 1988 Dec 15;178(2):413-7.
  148. Day IN. Molecular analysis of two general markers of neurons and the diffuse neuroendocrine system: neuron-specific enolase and PGP9.5. Biochem Soc Trans. 1988 Aug;16(4):454-7.
  149. Wilson PO, Barber PC, Hamid QA, Power BF, Dhillon AP, Rode J, Day IN, Thompson RJ, Polak JM. The immunolocalization of protein gene product 9.5 using rabbit polyclonal and mouse monoclonal antibodies. Br J Exp Pathol. 1988 Feb;69(1):91-104.
  150. Day IN. The diffuse neuroendocrine system: a molecular perspective. Mol Cell Probes. 1987 Dec;1(4):275-95.
  151. Day IN, Allsopp MT, Moore DC, Thompson RJ. Sequence conservation in the 3'-untranslated regions of neurone-specific enolase, lymphokine and protooncogene mRNAs. FEBS Lett. 1987 Sep 28;222(1):139-43.
  152. Day IN, Thompson RJ. Molecular cloning of cDNA coding for human PGP 9.5 protein. A novel cytoplasmic marker for neurones and neuroendocrine cells. FEBS Lett. 1987 Jan 5;210(2):157-60.
  153. Day IN, Thompson RJ. Levels of immunoreactive aldolase C, creatine kinase-BB, neuronal and non-neuronal enolase, and 14-3-3 protein in circulating human blood cells. Clin Chim Acta. 1984 Jan 31;136(2-3):219-28.
  154. Thompson RJ, Day IN. Measuring serum neurone-specific enolase. Lancet. 1982 May 15;1(8281):1126.
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