Molecular MethodsThe group has a history of methods development underpinning molecular genetic research, including developments in high-throughput, electrophoresis-based mutation detection and in end-point ratiometric measurement of copy number for highly polymorphic copy number variants (CNVs). A small sample of publications:
- Guthrie PA, Gaunt TR, Abdollahi MR, Rodriguez S, Lawlor DA, Smith GD, Day IN. Amplification ratio control system for copy number variation genotyping. Nucleic Acids Res. 2011 Feb 7; [Epub ahead of print]
- Alharbi KK, Aldahmesh MA, Gaunt TR, Rassoulian H, Ai Guthrie P, Rodriguez S, Boustred CR, Spanakis E, Day IN. MeltMADGE for mutation scanning of specific genes in population studies. Nat Protoc. 2010;5(11):1800-12. Epub 2010 Oct 21.